	   SnapGene      ¥ACTCGTCCTTTTTCAATATTATTGAAGCATTTATCAGGGTTACTAGTACGTCTCTCAAGGATAAGTAAGTAATATTAAGGTACGGGAGGTATTGGACAGGCCGCAATAAAATATCTTTATTTTCATTACATCTGTGTGTTGGTTTTTTGTGTGAATCGATAGTACTAACATACGCTCTCCATCAAAACAAAACGAAACAAAACAAACTAGCAAAATAGGCTGTCCCCAGTGCAAGTGCAGGTGCCAGAACATTTCTCTGGCCTAACTGGCCGGTACCTGAGCTCAGTATGTCTAGACTGAAGTATGTCTAGACTGAAGTATGTCTAGACTGACTCGAGGATATCAAGATCTGGCCTCGGCGGCCAAGCTTAGACACTAGAGGGTATATAATGGAAGCTCGACTTCCAGCTTGGCAATCCGGTACTGTTGGTAAAGCCACCATGGAAGATGCCAAAAACATTAAGAAGGGCCCAGCGCCATTCTACCCACTCGAAGACGGGACCGCCGGCGAGCAGCTGCACAAAGCCATGAAGCGCTACGCCCTGGTGCCCGGCACCATCGCCTTTACCGACGCACATATCGAGGTGGACATTACCTACGCCGAGTACTTCGAGATGAGCGTTCGGCTGGCAGAAGCTATGAAGCGCTATGGGCTGAATACAAACCATCGGATCGTGGTGTGCAGCGAGAATAGCTTGCAGTTCTTCATGCCCGTGTTGGGTGCCCTGTTCATCGGTGTGGCTGTGGCCCCAGCTAACGACATCTACAACGAGCGCGAGCTGCTGAACAGCATGGGCATCAGCCAGCCCACCGTCGTATTCGTGAGCAAGAAAGGGCTGCAAAAGATCCTCAACGTGCAAAAGAAGCTACCGATCATACAAAAGATCATCATCATGGATAGCAAGACCGACTACCAGGGCTTCCAAAGCATGTACACCTTCGTGACTTCCCATTTGCCACCCGGCTTCAACGAGTACGACTTCGTGCCCGAGAGCTTCGACCGGGACAAAACCATCGCCCTGATCATGAACAGTAGTGGCAGTACCGGATTGCCCAAGGGCGTAGCCCTACCGCACCGCACCGCTTGTGTCCGATTCAGTCATGCCCGCGACCCCATCTTCGGCAACCAGATCATCCCCGACACCGCTATCCTCAGCGTGGTGCCATTTCACCACGGCTTCGGCATGTTCACCACGCTGGGCTACTTGATCTGCGGCTTTCGGGTCGTGCTCATGTACCGCTTCGAGGAGGAGCTATTCTTGCGCAGCTTGCAAGACTATAAGATTCAATCTGCCCTGCTGGTGCCCACACTATTTAGCTTCTTCGCTAAGAGCACTCTCATCGACAAGTACGACCTAAGCAACTTGCACGAGATCGCCAGCGGCGGGGCGCCGCTCAGCAAGGAGGTAGGTGAGGCCGTGGCCAAACGCTTCCACCTACCAGGCATCCGCCAGGGCTACGGCCTGACAGAAACAACCAGCGCCATTCTGATCACCCCCGAAGGGGACGACAAGCCTGGCGCAGTAGGCAAGGTGGTGCCCTTCTTCGAGGCTAAGGTGGTGGACTTGGACACCGGTAAGACACTGGGTGTGAACCAGCGCGGCGAGCTGTGCGTCCGTGGCCCCATGATCATGAGCGGCTACGTTAACAACCCCGAGGCTACAAACGCTCTCATCGACAAGGACGGCTGGCTGCACAGCGGCGACATCGCCTACTGGGACGAGGACGAGCACTTCTTCATCGTGGACCGGCTGAAGAGCCTGATCAAATACAAGGGCTACCAGGTAGCCCCAGCCGAACTGGAGAGCATCCTGCTGCAACACCCCAACATCTTCGACGCCGGGGTCGCCGGCCTGCCCGACGACGATGCCGGCGAGCTGCCCGCCGCAGTCGTCGTGCTGGAACACGGTAAAACCATGACCGAGAAGGAGATCGTGGACTATGTGGCCAGCCAGGTTACAACCGCCAAGAAGCTGCGCGGTGGTGTTGTGTTCGTGGACGAGGTGCCTAAAGGACTGACCGGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGCAAGATCGCCGTGAATTCTCACGGCTTCCCTCCCGAGGTGGAGGAGCAGGCCGCCGGCACCCTGCCCATGAGCTGCGCCCAGGAGAGCGGCATGGATAGACACCCTGCTGCTTGCGCCAGCGCCAGGATCAACGTCTAAGGCCGCGACTCTAGAGTCGGGGCGGCCGGCCGCTTCGAGCAGACATGATAAGATACATTGATGAGTTTGGACAAACCACAACTAGAATGCAGTGAAAAAAATGCTTTATTTGTGAAATTTGTGATGCTATTGCTTTATTTGTAACCATTATAAGCTGCAATAAACAAGTTAACAACAACAATTGCATTCATTTTATGTTTCAGGTTCAGGGGGAGGTGTGGGAGGTTTTTTAAAGCAAGTAAAACCTCTACAAATGTGGTAAAATCGATAAGGATCCGTTTGCGTATTGGGCGCTCTTCCGCTGATCTGCGCAGCACCATGGCCTGAAATAACCTCTGAAAGAGGAACTTGGTTAGCTACCTTCTGAGGCGGAAAGAACCAGCTGTGGAATGTGTGTCAGTTAGGGTGTGGAAAGTCCCCAGGCTCCCCAGCAGGCAGAAGTATGCAAAGCATGCATCTCAATTAGTCAGCAACCAGGTGTGGAAAGTCCCCAGGCTCCCCAGCAGGCAGAAGTATGCAAAGCATGCATCTCAATTAGTCAGCAACCATAGTCCCGCCCCTAACTCCGCCCATCCCGCCCCTAACTCCGCCCAGTTCCGCCCATTCTCCGCCCCATGGCTGACTAATTTTTTTTATTTATGCAGAGGCCGAGGCCGCCTCTGCCTCTGAGCTATTCCAGAAGTAGTGAGGAGGCTTTTTTGGAGGCCTAGGCTTTTGCAAAAAGCTCGATTCTTCTGACACTAGCGCCACCATGAAGAAGCCCGAACTCACCGCTACCAGCGTTGAAAAATTTCTCATCGAGAAGTTCGACAGTGTGAGCGACCTGATGCAGTTGTCGGAGGGCGAAGAGAGCCGAGCCTTCAGCTTCGATGTCGGCGGACGCGGCTATGTACTGCGGGTGAATAGCTGCGCTGATGGCTTCTACAAAGACCGCTACGTGTACCGCCACTTCGCCAGCGCTGCACTACCCATCCCCGAAGTGTTGGACATCGGCGAGTTCAGCGAGAGCCTGACATACTGCATCAGTAGACGCGCCCAAGGCGTTACTCTCCAAGACCTCCCCGAAACAGAGCTGCCTGCTGTGTTACAGCCTGTCGCCGAAGCTATGGATGCTATTGCCGCCGCCGACCTCAGTCAAACCAGCGGCTTCGGCCCATTCGGGCCCCAAGGCATCGGCCAGTACACAACCTGGCGGGATTTCATTTGCGCCATTGCTGATCCCCATGTCTACCACTGGCAGACCGTGATGGACGACACCGTGTCCGCCAGCGTAGCTCAAGCCCTGGACGAACTGATGCTGTGGGCCGAAGACTGTCCCGAGGTGCGCCACCTCGTCCATGCCGACTTCGGCAGCAACAACGTCCTGACCGACAACGGCCGCATCACCGCCGTAATCGACTGGTCCGAAGCTATGTTCGGGGACAGTCAGTACGAGGTGGCCAACATCTTCTTCTGGCGGCCCTGGCTGGCTTGCATGGAGCAGCAGACTCGCTACTTCGAGCGCCGGCATCCCGAGCTGGCCGGCAGCCCTCGTCTGCGAGCCTACATGCTGCGCATCGGCCTGGATCAGCTCTACCAGAGCCTCGTGGACGGCAACTTCGACGATGCTGCCTGGGCTCAAGGCCGCTGCGATGCCATCGTCCGCAGCGGGGCCGGCACCGTCGGTCGCACACAAATCGCTCGCCGGAGCGCAGCCGTATGGACCGACGGCTGCGTCGAGGTGCTGGCCGACAGCGGCAACCGCCGGCCCAGTACACGACCGCGCGCTAAGGAGGTAGGTCGAGTTTAAACTCTAGAACCGGTCATGGCCGCAATAAAATATCTTTATTTTCATTACATCTGTGTGTTGGTTTTTTGTGTGTTCGAACTAGATGCTGTCGACCGATGCCCTTGAGAGCCTTCAACCCAGTCAGCTCCTTCCGGTGGGCGCGGGGCATGACTATCGTCGCCGCACTTATGACTGTCTTCTTTATCATGCAACTCGTAGGACAGGTGCCGGCAGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCGCTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATACGGTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAGGCCAGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGCTCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGCGAAACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGCGCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGCCACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGTGCTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACTAGAAGAACAGTATTTGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCTTGATCCGGCAAACAAACCACCGCTGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGCAGATTACGCGCAGAAAAAAAGGATCTCAAGAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCACGTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTTAAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCTGACAGCGGCCGCAAATGCTAAACCACTGCAGTGGTTACCAGTGCTTGATCAGTGAGGCACCGATCTCAGCGATCTGCCTATTTCGTTCGTCCATAGTGGCCTGACTCCCCGTCGTGTAGATCACTACGATTCGTGAGGGCTTACCATCAGGCCCCAGCGCAGCAATGATGCCGCGAGAGCCGCGTTCACCGGCCCCCGATTTGTCAGCAATGAACCAGCCAGCAGGGAGGGCCGAGCGAAGAAGTGGTCCTGCTACTTTGTCCGCCTCCATCCAGTCTATGAGCTGCTGTCGTGATGCTAGAGTAAGAAGTTCGCCAGTGAGTAGTTTCCGAAGAGTTGTGGCCATTGCTACTGGCATCGTGGTATCACGCTCGTCGTTCGGTATGGCTTCGTTCAACTCTGGTTCCCAGCGGTCAAGCCGGGTCACATGATCACCCATATTATGAAGAAATGCAGTCAGCTCCTTAGGGCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCGGTGTTGTCGCTCATGGTAATGGCAGCACTACACAATTCTCTTACCGTCATGCCATCCGTAAGATGCTTTTCCGTGACCGGCGAGTACTCAACCAAGTCGTTTTGTGAGTAGTGTATACGGCGACCAAGCTGCTCTTGCCCGGCGTCTATACGGGACAACACCGCGCCACATAGCAGTACTTTGAAAGTGCTCATCATCGGGAATCGTTCTTCGGGGCGGAAAGACTCAAGGATCTTGCCGCTATTGAGATCCAGTTCGATATAGCCCACTCTTGCACCCAGTTGATCTTCAGCATCTTTTACTTTCACCAGCGTTTCGGGGTGTGCAAAAACAGGCAAGCAAAATGCCGCAAAGAAGGGAATGAGTGCGACACGAAAATGTTGGATGCTCAT  5K                           "                  %   0   !         '   )      
               #               %                                                         $   (   (         3          "   1   &      +            !                           $   '   (         (            ,               	                                                                                                       '   !                  $               "   
                  !         
                     
                                                   $      '                  "                                             	      5   )         $      	               (   2         !   :   #   #         !   
      )                         )                         .      !            %      7   2      "                     "      !         iÞ1ºx	y	12ã—ðY S ñêß´z	ƒ	Q2äá¼³â€ $ |ÎÅ12;
(˜ÉZ ÒŠA”!®j­î»È	ð/½õ,3)­	øñ T Þáz	‡DGn{	„	Xdíl=’ ‡ºlÿ	
*
A
‰
ïšâ¨ãõ� : Q�zš·	ûRÃåÇ w½Øš ] òJëà‘µ»Ð�ÌÜíì€ˆ¬3ÛLj|´" ï  G¤ÏÞ‡�ûþ2»¾ÒA~	<
„
)ÐB_)okºÐJ[ N W }£¬}&÷s©	•µÊZt™¯ö#DŽ¡* % Œ ¢r	‡	
àÒME¶ Æ3 '™° ™Ä ÀÊ eú"fkíA¤O¼É	
ñ‡·NV-®Ç-n�ê·j’¨ò ›'ta�¢öåTuY
¡
8{ì‰šßo4uŒ2\†0i% Ù p‹ãB•Â—¯¾®ey•™Õï3M
•
[m< _cöT¨;*Þ®¦0 b _hÓé†Œ´S:™M¨¿Ãè	-3g&0>¾EY–¾ýey¶!Ó+†ºã
yù! U OzEÜß{„w¹Ð?E|	…	ý	
+1VYeîÎ@]“i­Z« c®ÝZ
‚ˆ oÇ÷“ÊÓ ZËµæŠ�iÃQdrm…†' ýh7ßâ2Da¿ÜRHbqÌCØùþ•Õm‚‘ªÒ>±üL©Õ=)  *:ˆ»Ïëx€^ÛÙ„±]
¥
N™œÉôxóÂ%›ãËè€ùWoá} Á =½		í	ù	
B
Š
¸Ïðqo­äÒö‘
 ˜ �°)ü+
,Ýä‚ ö 7m 

£°«ðô6ë©ø ¾eIã"	á9ü…µëöËJY› ; � R€{ÖÛ²	æ†È DS¡d¾Ì¤ê# ZžLgsýi·\Ñ[âŠù ›¸	×	hÄ-xƒ‹ÙåSbk›Ò 7 î9á’¶¼+CFÍî¬‰­ÜèQI\ž ^ sKöìs?¹ä +Œ§ÑíˆÐ�›Œ4ikxy%µŒ &6FJ�Œ¯Ñú‘Ý®Åæu9N’}~‹ú óˆæUHÑ~áÜHÆýM…ÿ·Hf•% H¢áç…ŠüQÎŽ—¼ÊB�	§	(
?
‡
»CÙ*lèÎÑK¦C„wŒ – 5­‚5'		 	TÖ*ƒúX©Hbdƒ … ‡ ” ¥Éß>3¿Ä	/
1
=
…
ÔQ{á’ÙÛèê.–Š\ ä ê ð !§ÐV×ˆÊÿIgÓÑ`p¦0»MÖ^ˆ %~óøQ©ž–g´$E˜f‡ @ D ­'t4	–	ª	Ë[ušS+U X -=~/Ã	`
¨
H¶°ð÷�¢Œ - O ¡ ¤\£ÍÒD!SC<oË ‰ ©ËÁêµç}Ý' t4— & k£O	
7
ºãÓ·F � èl	ˆ	½	Ÿá0�NVüi~T l¼×¢Æs	ù
ÌŒ-ì¤²?ÅyÜZ�¬·é ,Ç4ad·êí$(Zšü@¡“Eš!{ J3
y
Á
8±eÅïÁËìI 1 !1A¢q¤Rdš!7«  Ý @MF
Ž
Î
”ÉÝø!Ïk}( f¼dg?c¢¹s½
&OWm0¬³È¸H)¾ó û¬SB¥Pþ¬Úòˆ‘¨¯o«iÑk“Š j#ƒKÁ	³¸œX%.ŽæÚ©R$ ÙƒílÇî=·gŽ”Ê	Ü	�4d¯]Ó„·@‰‹.yš¨ëOýjÁ¾( ì ÿu©¹ïð^JÎ 	Þ	V
Z
ž
¢
(ä|íor›Bvì��¦^al@Ãé1È( f Ñ æ œ9FX„böOv÷æõD	’	d
}
¬
Å
tðàpº`þ	3Z/Æó`jnx  Ÿž£v_	i
m
±
µ
£9hŠ¹5N‡? (<054V�ÁUá	i+F2]4-3 Ú qŒä
C«F–šÖTi´d‡A	Ô	%
16f×Þe¸`“´îUbù—©*þ&+LA?B›  {…ðay°ä-¯fzð%	
E¬Löÿ(z�½ß5 M€ n—µ–Ãá:˜¿×ò%”4ŠÇ	+	\n=!dƒÀíO¯§\" ­ ‹ÌqƒÌ	N
–
{¡É÷6 {‹œ¼<_žªøÿ'¡–ð$žØž1 c ÷Wn‡.7L[$NQ©ÀÄ.4ûð¿ã†—þ:Efv·Cr"½,Î×Æu& ò i²ÁÛ!»Š`�©Éšž¬�–‘X`?_˜ÕF	†“
þ^zNÀ `0µé­Þ;Õé	7=h —Úé¬¿ÔñÓQÔp‡,ú+ Ô#ÅÒê%Ùø(OTû?Wñ\iÓ
ß
è
ô
þ
	Ÿ±'1§ZžzAD»ä¤# # {Ñ@“ ¬Ýíw	:
ïâ»¬÷ 9 PÝày�º†ÛFm™¶	þ	W‘iî{Ÿv×  M V î F|€úö¡Ñ@q	}	†	ƒ
ÏA^”˜nj®! a Ø …¡õxL§
L
X
”
 
,2Zfl¶7üÆ :Œ¶[¹h yÞ1Ûp´ü	*öø”ÔÑh¨ÂÔPq õ Îw¯<]¼ƒ°û
\
¤
M›ÈªÜóçênVã
| Y½dKrh[‰øÚõ…c‚ËäšX %5Erí‡ù*~ÐG«Å~Ätxù ã é 
	SÓzÍ¥BLWƒa‰Õ‡ , ? C   ,<[ÌCò•	_
§
P¨B;~ïRen†Ê »éçN	6
ø
Ëæ‹žÄûYhs3 I`¶E
x
�
À
Í
7dj6ëz$ Øi‚«‚cÆ<b¡r“Ž²Ùc�›ƒ?lx²åªG(hÀ½Q'  Ð þ8ƒž3NuÀIÍ‘	à	U
h
|
�
°
Ä
ïnqýM�¥]`Åò3Ç>m( mŠ–z´ï	`àãñ$ES³c@	

$
Dz0Öõ '’È»�÷%&>ïš ± $'èÝú �žúÿ–è¦�«ÓDC’	ÖýÅ" 8 L Ð?xÜù�ì…Ú¦µ	µ6û�ÅuºÖÿ~( X¼Íì;J\q†ø 0)Ú¯÷Ùû	
šõFÄÃò„wé~�UpâWø{ > B è +;BèM	”	D
^
Œ
¦
OÊycÌúXyÔ  l‰°
y�_�Mç²?	�	g
¯
y�ô¥&œä$\Ä™l ¯	>I[pœÙ�	ú	
C
f
‹
®
xEÄñƒtÕÓ÷z, k · ¼ Æ Ó ÄÅHZoïv					˜	¬	vw¹º¿ UVpqrs®ÓÔóôbcp’ l Ô æ
		£	­	î	»1ÀWîõ1åq“ ¸ ½ Â Ç Ë Æ•ð�¾wðI	™	Ð£r59¯8d „ý	¤	,
ö2Èõæ-rƒ”  F h m Õ �±çF	ï	-¼ÁÍ	 *	[	t
¼
¼ï= ™ ž®	2ÞXå ¾ óÿSÈ‘€Ÿõéª ¦ ¹ Ã È ÷ Ç¿n"nJ	R	U	X	ÑòIõœì6¸e Ì Q÷
Ù
î
¤±â¤ñb]Ø°° –ñdÂ8qx¨ñ6	š	ò	 

Ç
Ir¬s7o:9ùu …¸ˆ}xæ	:ù†jJ´¤(. f~Y_|`Ôä—7LÈ÷Éö;Ðß„ /?¡ Ð•j	¥	-
o+ø²• ¿ÃMJþ	#	b
k
ª
³
&âý¶á²ì÷^3ÌKçLZsœ ž Ö ²�|Ë
.8õ�Å  < i ‚þ×=	G	³	ð	½ç�  G n S€@ÂÚ © ‘kèÜžÎ‡ÉŽ¯  Z à(	\	Å	b}  I | ÊN	:	u
½
Ð¢eÍðÜ  v ú ·� 		0	e	"½TYÊò¿të Þ1EçÌ+a	H€+¥> š -BšŸÛõ<]‰ªË‹!¯	Ä„;»3=Yaƒ‰ßæ   ´ UhtwzþjÒ\ãœ¥Å[¸ßPÐTœ¶‘ÓÜ p � [ù[¸%Ø	o
·
LÄÕùyŒÚcl8A ŸMm|¥ú¹	ã
riŒÖV.„æ2Q Q ï•²“q1ÝRÐÜ•�± ¿ ô ÉÏFXâ·½DGÎŠ®>éƒJ4|«¢� / Ti Oöµ « :U©’�,ï­ê]ühŸ” _ ºŸÑÒæ5jlÚy�Àí&f  º Ä É “ýmí@Àåo}�ê¦îõK	S	V	Y	¡	CGó/S7;¶  § ø È>L÷¨#ÒÞ‚œJ°ÓöÎÃ t¥t!,o€‰E�-�zâ9¹� '7G¦.±Þ# x²ÆO�‰–=ƒ ) £ Í v�û’ø‹kò:~^ÙäŸ6 �^°Ò³RÃ
[ç}ãH#ÍH   Kç6¯Ú
ï
¥½v¥c“À±Œ±qû'' ô6)d‰ç-27vÔ#Ò©â©IU€�þ!Ns†­ ÄI>_àFg»! µ*—�òe’¦žÃ9óyò7	ã	!
€
È
”¯uÎ‰;:I³úv–N Q§Iš›	ó	
ÝÇJØËà ã¾VÕrW‚nt¸8pÖ/ ‰Í­0³‚	Ç	¼ô+( \ †¹I~Ïk�ËìCyë)
@
ˆ
cú‡«kÂÚK™§™ ‹ «£†ý½¨	
ß˜Ïõ"CLÃD�µ)$ 
^šsâè‹ìR˜˜ç	;MzDU^b•dµ,mé‹Ò…x…¥/ g6ƒ`aå
BU×ûhÉYª<c„…  — )9Ž6Ø(		ì	ø	˜·+Êø÷àÑ ü¶ÐZáÕâ!	Ö	à8g„´,ŠRÊIÑ6 I®¸}à‡šü8M‘H�$Še" „ † “ • ¦àæ=4H–Ã		€	¦	'
.
0
>
†
ÕàºØÚçéù-/v‚]
 ¢Ñ3	 R ³—‹ ˆ ¨ÊÖ¡ÀÅk	|â,Üë±U– Ü  0@?2
éìp“ÈûQÎî'D  »ìJ¶f�À	Û	%3\Ò§¶W™«§Nü‰ å ë ¨¸EWõUœÿC	^	c
l
«
´
'sãh¢g_1Y?è,_ Ëh†‰	$	*	Ýþd·³íaø)¼4NAL[�×�! ñ À"ÄÑºØN‰ >KVÔ[<Ùâðq¼oÍM£t × ô9
k—h9µö $4Dqx}³úª©ôæã™O
 + Ÿ 	w
¿
Ì
R‚gˆ Ï ³‚&#ù	
�/Ÿö¤%FÆ! = A K Ìÿ/L(¥Ø>	´	�v¹TV j ®uØH	Ž	—	«	¢¾‚íò 
7 E ƒÌ, ¥ òm5	Q	ñ	Ø
í
è\›× .>}‡”i	a
©
%ø*IK±:£Þ
 �ý<	€�®   H Y u 0æ	'	/	Ä	!GÉñsÛ  o TA{Ã<Z·ÕU`‚øÏ� . P ª TÎE±hN=ÏÛg”¡�° ~ ’ül¤|é¥Ý 	BåD¯€Ò¿á8 ( ¢ ¥]²°"Ÿ¼|"‚pÌG â5Pc�,Ó�ò
®TmtÍˆÃÊH²E [ Š ™ªÌëêÆ	
b~Þô!Â˜  µá¶
gÉ+‰QÐ5 ’ <Â		2	èæTí&u� ·¹ëôTŒ)	]	¿	r[cf(X~¢+ p"
8
v
¾
£õ J Ël
P	�	¡¸ìñÿ   t 	.	;	h	 $ÈJYÔT�ÎÝ ' } 4O¤»äÑÂfG±DF ‘ ¸é		1	¾	aqZåóSWˆÁì%€Ï  s 3!	-	g	Œ	# ÇXëþE$  	 w Ž � � f	‰	Š	‹	^_`pËâãä12OPQR�Àêý^D 
 x û ŽÁm	¾UÌ3‘Öï�uj_JU' `m2ªÔã^šÂÙ*(ÇÉÍ	]#,é.åí¥Þvz¦[ž©íV  y ÀØÅF�£Èb	n	t	�VÍ@ÝÝ­;K ü ß½è'ÍÅ,
�„¿?ORU×ðÆ‘?ê ’˜²–6Ð	ú
I%…4’³k¸` cn›Ü_›Ã¸ë…$-<ê/¼%ž¦ßŸàîW › M�éCaäÚ=	Š)Ê°	}ÅÎ
€æ[›îýZ"   -3«ÕÈÌbeŒÈÛ¢×>e¢¤bw{”§FŠ˜›ª|ç .ö+^«5"^îx)48A‰•„\" ! G€so	u	4
z
Â
Ž¦9Æ¹àf
A£Uf·ðí<  6 µ VQÆä�r
º
£ùÂa|Ñ®Âsý z ÁÙiux{ÿKkÎ:]‡Éc	ÂW²Î\óÆ&JÚÝ  �¤Ó/§�¾Qú³Þ�Þ’ÌÔL ‚ ÿ \¹	ÎÙ	ö	
:@…S¥Öú›"m³ "2Bàú£±ž	@rË§’8¬ q ¾\é(Æ&Î	‚MPÅSV}eÇ)�ÛB ë)9B 2 4 ¯ ý 8…-p
¸
À¿¬Øñzd@  A¦Nûº	Ñ	Ü
ñ
û
•"&€>´ÐW/)lýRa ± “™—JÁÞ×5!l~/3  N}ù"†®…çò Þ ³n7;G
P
�
˜
Ï
ä
sÊjÊ�“ ÚŽ¹ R ðéÄh0¹'.P01à–È²áïX	 œ
ì<Æô ¢Ý%rº&¯(Ÿ´ÉÑYs¹I ¿5 dgù&oÁ`–œ½e³@d”£Ô9Nä2St¾Â†%=ëXˆ™½ÞSnxt§­Ý1*âi‘§) NüDYb­ÊÜÛY
Cv¸¾Q�Ïÿ>Ë0Æý‰’Í?��©\œ°K¬Òl À êÚ¢ówÎò¯Á$ïp5¬n� œ fCH±	~êaj£éÿ$ Ž8õ‹ÐåTr>Gã‹¦*BE­ÏÛ‹å çPh„þ[w¶G}”‹ ¡È4U¬Ö„É‰PÍf�É&P‚‘Ø¥ç•¨G‹c	 .$Â	�GfT kj¼	´¹£&/�>¶xÛœ«}èS  0 +Lc¡Ü÷£#Y?c|’™Hª R>¸ý«®ˆŠ/$iÐÙ½ e ;/4îï]ôÝ	
¸*A¹Eëk.Âw( ¬ „9xªÖ,p“‚ÆË	Ó	«5Key 5Œz‚Š–›^©¿ìýKþ@ •#
2 Úö/V÷_m¨È¬-6Z«ð#Ph�•Ò
Þ
ç
ó
ý
6�W_°ï
^—Ô…9uB@ÒP…+]¿ " ` í ’ «õ Kl˜p	v	K
W
‚
“
Ÿ
máíz‹ž¸g ô vg»Ï[
£
)LÓ}sÐÛg§Ábm	! â ºHñ_	5
÷
Òå§A6:}î¤AKV5`êÉ2: •× ªî#�ðbtÅ; ÿœ’ß	#
T
{
œ
Ã
±b�çšîpœÇCkwºBŽ‘_'g¿Äñü ¼î2=P# 7 ç Wk:…÷AwæøŽë®çöL	“	´Ã5¤úb#[}Ãx˜þk# ¶ » Å Ê Ò Ã”GYn›î�~åï¢	e
­
uD0Ãÿ
T48Ò0aoy  g �E	Z	s
»
»Çô< þRÇcPÁp!§žöT	W	~
Æ
HñôHáqan¯t·! ·Â|  LŸÏX^{_wÓå	j
²
–nài±³6]÷ÇÏ'K
 ¨ ?jÊ
�7ô€ÙÄ  { ù ÉÝM¶ŒËß9	`	d	*XaÏ|) € ³ ,™ÚøvyôZl;¤ˆ©Ê$n
¶
â
Ãqƒ¤:K‹ºÔOµ1ˆPÛÞ@ ”¨Wp0‚û3{´“Ž =žôF,.ÙRÍ:Â uæ5-ÂŠZjwGŽ¿ˆ•ã<ž5& ´)(¦½16u‘¥™Ô"V�â	“¨Ž× =ß^ßÕº.M   	]r¬ë/—²jLyªT]a”Áóc+˜'Š—B„´ (8H�û·Ï×àßÕ	ë	÷	
A†ß7™f³û�Gœ#‰ ƒ Û §ÕåG&
ßë¹Ç×úP°Íÿ,C) Dº
›=UµZe…ˆB	Ú	;$2g¡ØÜ¦µïV˜ª»Mû>n@œ * Î #3Cw²ùjŒ¨óåâN ¤ ñ.K×¤×
ì
ŽÖ	6 |†zåü“&	F÷ );_r9­  áSûbŽ+±œ°g{¯ñŸ	
­AMls{®Ì¾Úà“ !�7 ˜¶;´êóS‹
e	fÈ*P¡* oIÁS€°ôC  r 2À	,	]oÆWÕî‡Žé$]ÎCI. ‘_¿—©±ÄÓâ]™Ø&)•ÄÇ'5ÈÏ	
ƒ>\"èNQ~ä$T~„ÝÜ¨ì:  LbŒè|Úw¡Ö7dˆ”�£—! 5 PÍ9r†.q
¹
¦Á¢øŒ½Á`òù	{¢²e%rÙüŸ 3 ® þ 7„°�	Í	õ	9?¾Ê¦|« (²AŸ( ° :O
—
Û
ð
ÀÉ!=Ÿ­Ù �.ñü ¡ø%Àè$Ó/8MãRÁ‡˜;w®'sÅXr0áÇh¦% 7XeŠÛBqÙuA€=/¡üvÍñÀÌäÿ#�OgvµF`èmþ Ç*ˆO%»	��"F=‘GSb7 d õ.38QwÕo§Y\ªóüOªÅÒ	Ñ
Ý
æ
ò
ü
5ªJV	–	ÿt‡¸D�#?¾ÑJ?-ÏØ*¼	v2 á ó ”Öí"‘faŸªÄ:ôþ›Ÿk‘—"
J
S
�
’
›
ö
K°a@™Ï|ŠJ¾ûÿ4_»1O jÂšŽ ­³Â4G"mw—" ² ¶Ü+˜µóY‹ÊWz^8	ä	É
á
 •p)`mß
6´0{ØO ³å'¼“§˜ó’YvÖØ‡”<;Á% Ôú¶êß<Y„ê	Þ˜ÛêK©ú\ÀòF—¯ºÌˆ R*J›®ÖÖ
ë
i­Õáq  1¨
#ÔÜR†èó aO~9œ	ô	8>ÈÙ Õ‡¢-û $Æ¿ÚPpØt@Xò<Ð
å
 uÌËŽu<Eq�ç¥" à Õäì&´XVý]jI
R
‘
š
à
õ
ÿ
o²(3l{½º×$0 Óù)8XƒÕ
ê
¨[ŸE–¡¹Û! ß ëWoÖ×UsüH
Q
�
™
Ô
é

tË2kBCD”•9:;�¼åæ  .j  qGACNNNNNNGTC,CCAGGCCTGG,GATCCGGATC,CCWGGTACCWGG,CCANNNNNTGG,CCAGGNNNTGG,CCANNNCCTGG,CCAGGNCCTGG,GCACNNNAACGTTNNNGTGC,CACNNNGTG,CCNNNNNNNGG,AACNAACRYGTGCGTGC,GCACGCACRYGTTNGTT,GCACNAACRYGTTNGTGC,AACGCACRYGTGCGTT,GACNNNNNGTC,GAANNNNNNNTTGG,CCAANNNNNNNTTC,CACNNNNGTG,AACACNNNNGTGC,GCACNNNNGTGTT,GCANNNNNNTGC,GAACNNNNNNTCC,GGANNNNNNGTTC,CAGNNNCTG,CCAGGNNCTG,CAGNNCCTGG,CCWGGGCCC,GGGCCCWGG,CCWGGGCCCWGG,AACNNNNNNGTGCACNNNNNNGTT,GACNNNGTC,GAANNNNTTC,CCWGGTACC,GGTACCWGG,CCWGGWCCWGG,ACNNNNGTAYC,GRTACNNNNGT,CCWGGYRCCWGG,GAAGNNNNNNTAC,GTANNNNNNCTTC,AACGGCNNNGTGC,GCACNNNGCCGTT,GCACGGCNNNGTT,AACNNNGCCGTGC,CGANNNNNNTGC,GCANNNNNNTCG,CGATCNNNNTGC,GCANNNNGATCG,TGANNNNNNTCA,TGATCNNNNTCA,TGANNNNGATCA,TGATCNNGATCA,AACCTGCNNGTGC,GCACNNGCAGGTT,GCACCTGCNNGTT,AACNNGCAGGTGC,GCCNNNNNGGC,AACNNNNNNGTGCMC,GKGCACNNNNNNGTT,CCWGGNCCWGG,AACTGGGNNGTGC,GCACNNCCCAGTT,GCACTGGGNNGTT,AACNNCCCAGTGC,GACNNNNGTC,GAGNNNNNCTC,CCWGGTCTC,GAGACCWGG,GATNNNNATC,GATCNNNATC,GATNNNGATC,GATCNNGATC,CCWGGCGCCWGG,ACNNNNNCTCC,GGAGNNNNNGT,AACNNNNNNGTGCAG,CTGCACNNNNNNGTT,GATCATGATC,CCWGGNNCCWGG,AACTGGNNNGTGC,GCACNNNCCAGTT,GCACTGGNNNGTT,AACNNNCCAGTGC,AACNAACCGGTGCGTGC,GCACGCACCGGTTNGTT,GCACNAACCGGTTNGTGC,AACGCACCGGTGCGTT,GCANNNNNTGC,GCACNNNNNNGTTCGAACNNNNNNGTGC,CCTNNNNNAGG,GCNNNNNNNGC,CCANNNNNNTGG,CCAGGNNCCTGG,CCTGGCCAGG,CAANNNNNGTGG,CCACNNNNNTTG,TTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAA,GCACNNNNNNGTTTAAACNNNNNNGTGC,CCAGGNCCY,RGGNCCTGG,CCWGGGNCCTGG,CCAGGNCCCWGG,AAGNNNNNCTT,GAYNNNNNVTC,GABNNNNNRTC,GAYNNNNNRTC,GATCNNNNVTC,GABNNNNGATC,GAYNNNNGATC,GATCNNNNRTC,GATCNNNGATC,GTYAACNNNNNNGTGC,GCACNNNNNNGTTRAC,GCACNNNNNNGTTAACNNNNNNGTGC,GATCNGATC,TAACTATAACGGTCCTAAGGTAGCGA,TCGCTACCTTAGGACCGTTATAGTTA,CTCTCTTAAGGTAGC,GCTACCTTAAGAGAG,TAGGGATAACAGGGTAAT,ATTACCCTGTTATCCCTA,GTTAACNNNNNNGTGC,GCACNNNNNNGTTAAC,AACNAACGCGTGCGTGC,GCACGCACGCGTTNGTT,GCACNAACGCGTTNGTGC,AACGCACGCGTGCGTT,TCCAACNNNNNNGTGC,GCACNNNNNNGTTGGA,CAYNNNNRTG,AACAYNNNNGTGC,GCACNNNNRTGTT,GTTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAAC,CCWGGCGCC,GGCGCCWGG,CCWGGNNCC,GGNNCCWGG,GATCGCGATC,AACNAACATGTGCGTGC,GCACGCACATGTTNGTT,GCACNAACATGTTNGTGC,AACGCACATGTGCGTT,TGGCAAACAGCTATTATGGGTATTATGGGT,ACCCATAATACCCATAATAGCTGTTTGCCA,ATCTATGTCGGGTGCGGAGAAAGAGGTAATGAAATGG,CCATTTCATTACCTCTTTCTCCGCACCCGACATAGAT,AACNNGCACGTGCNNGTT,GAACNNNNNCTC,GAGNNNNNGTTC,CCAGGWCCY,RGGWCCTGG,CCWGGGWCCTGG,CCAGGWCCCWGG,CCAGGWCCTGG,TTATAACNNNNNNGTGC,GCACNNNNNNGTTATAA,GCACNNNNNNGTTATAACNNNNNNGTGC,GAACNNNNNNTAC,GTANNNNNNGTTC,GGCCNNNNNGGCC,AACNNACTAGTGC,GCACTAGTNNGTT,AACTAGTNNGTGC,GCACNNACTAGTT,AACNAACTAGTGCGTGC,GCACGCACTAGTTNGTT,GCACNAACTAGTTNGTGC,AACGCACTAGTGCGTT,AACNNNAACGTGCNNGTGC,GCACNNGCACGTTNNNGTT,GCACCCANNNGTT,AACNNNTGGGTGC,TTAACNNNNNNGTGC,GCACNNNNNNGTTAA,CACNNNNNNTCC,GGANNNNNNGTG,CACNNNNGATCC,GGATCNNNNGTG,GATCTAGATC,CCANNNNNNNNNTGG,CCAGGCCT,AGGCCTGG,CCTCGAGG,GATCCGGA,TCCGGATC,GGCGCGCC,GCGATCGC,CCWGGWCC,GGWCCWGG,GATCGATC,GATCATGA,TCATGATC,GCGGCCGC,CCTGGCCR,YGGCCAGG,CCWGGNCC,GGNCCWGG,GGCCGGCC,RTGCGCAY,GATCNNGA,TCNNGATC,CGCGCGCG,CCTGGCCA,TGGCCAGG,CGCCGGCG,GTTTAAAC,GATCGCGA,TCGCGATC,TTAATTAA,VCTCGAGB,CCTGCAGG,CRCCGGYG,CGTCGACG,ATTTAAAT,GCCCGGGC,GATCTAGA,TCTAGATC,CACCTGC,GCAGGTG,CCTNAGG,GATCGAT,ATCGATC,CCTCAGC,GCTGAGG,GCTNAGC,CCTNAGC,GCTNAGG,GCTCTTC,GAAGAGC,GGTNACC,CGGWCCG,ACCWGGT,RGGNCCY,CCTGGAG,CTCCAGG,GGTGATC,GATCACC,GATCNGA,TCNGATC,GGGWCCC,GAAGATC,GATCTTC,CCCWGGG,TCCNGGA,TCCWGGA,RGGWCCY,TTATAA,AGGCCT,GACGTC,GTMKAC,TCCGGA,TGCGCA,ACCTGC,GCAGGT,GGTACC,AGTACT,GGYRCC,CCGCTC,GAGCGG,AACGTT,YGGCCR,RAATTY,CTGAAG,CTTCAG,CACGTG,GRCGYC,AGCGCT,CTTAAG,ACRYGT,ACCGGT,ACTAGT,CACGTC,GACGTG,GWGCWC,GTGCAC,CYCGRG,GGGCCC,ATTAAT,CCTAGG,TTCGAA,GCTAGC,GKGCMC,TGGCCA,GGATCC,GRGCYC,ATCGAT,CACGAG,CTCGTG,GGCGCC,GAAGAC,GTCTTC,GCATGC,GTATCC,GGATAC,TGATCA,ACTGGG,CCCAGT,CTRYAG,RGCGCY,AGATCT,GGNNCC,CTGGAG,CTCCAG,CTTGAG,CTCAAG,CGATCG,GGTCTC,GAGACC,YACGTR,CCNNGG,GAATGC,GCATTC,WCCGGW,GCAATG,CATTGC,RCCGGY,GCGCGC,GAGGAG,CTCCTC,CGGCCG,CCCAGC,GCTGGG,GTGCAG,CTGCAC,CGRYCG,CGTACG,CGTCTC,GAGACG,CCATGG,TCGCGA,GDGCHC,TGTACA,TCATGA,ACATGT,GTATAC,CCWWGG,CTCTTC,GAAGAG,GCNNGC,CCRYGG,GTTAAC,RCATGY,TACGTA,RGATCY,GCGATG,CATCGC,GCAGTG,CACTGC,CCCGGG,CCGCGG,TTTAAA,GGCGGA,TCCGCC,GAGCTC,GATATC,CTGRAG,CTYCAG,CAGCAG,CTGCTG,GAATTC,ATGCAT,CATATG,GTYRAC,AAGCTT,GTNNAC,TCNNGA,CAATTG,ACGCGT,TCCRAC,GTYGGA,GCCGGC,CMGCKG,GCCGAG,CTCGGC,CTCGAG,CTGCAG,CAGCTG,GTCGAC,CTYRAG,AATATT,GATCGA,TCGATC,GACCGA,CACCCA,TCGGTC,TGGGTG,WGTACW,TARCCA,TGGYTA,TCTAGA,GGATC,GATCC,CCWGG,GTCTC,GAGAC,GCWGC,GGNCC,CCSGG,GGTGA,TCACC,GGWCC,GCAGC,GCTGC,CCATC,GATGG,ACGGC,GCCGT,GCNGC,CCNGG,GCATC,GATGC,ACTGG,CCAGT,GGATG,CATCC,CTCAG,CTGAG,GGGAC,GTCCC,ACNGT,CTNAG,CAGTG,CACTG,GACGC,GCGTC,CCCGC,GCGGG,GANTC,CGWCG,TCNGA,CCTTC,GAAGG,GTNAC,GAAGA,TCTTC,GAGTC,GACTC,GTSAC,GAWTC,GCSGC,CASTG,ATGAA,TTCAT,ACGGA,TCCGT,CGCG,CCGC,GCGG,GTAC,AGCT,GCGC,CTAG,GATC,GGCC,CCGG,CATG,RGCY,YATR,ACGT,TGCA,AATT,CCTC,GAGG,TTAA,ASST,TCGA                                                                                                                                                                                                                                                                                                                                                           0                                                                                                                                                         
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               0                
                            	                                                        
                        	                                                      %            	                  	      I            	                                                                                    $                      7         (   $      #   0      !   ™   J         	      !      Y                                                                                                                                                                      0                                                                         
                                                                                                                                                                                                                                                                                                                           0      
          	                    
        	                    %    	      	  I    	                            $        7   ( $  # 0  ! ™ J   	  !  Y   j¢  k²  kÌ  l  pj  u*  {|+®Q\-ÆX~ÕaÖ×8‘#¾ÕŒ‹G¦<÷Z
¢
‘¸SBçï”4to+5HÑ`91s²	s²	d
¬
Ñ `ƒ¬X–äíî=BKz.õ‡Á	d
¬
ß
.4ò4`ˆ¯öÿ˜WŠîmr³%a,ÎÑ›;‰û	™ZŒ‹Œ‹=Œ‹Z€ ÂÚv¦XÔ<'ŽJ
’
©_jý[)Y¿ý[V)öŸKöì ó~q~J�Ì	{ÙEó€
Ñ/¹÷ÑÒ›Îý€Ù7;	f©qüŒìÛ	¶ì   [nÊï  'Ï‡kþÒTo\oaq±
g‹˜¾Â=D•dµ*x)	»(8×:k+î¨‚cxOö#­) Ê2¿0Ö0LÚt<ËŽÒ/iíÒ!Ð×ÿ/0‹˜Dx·	Ò/õš ¯	WÖ£këÂRi
±
ÇüÐZáRÑ.±à õ
{0ÿ¾>Ø‚kÆ“É	ŽcƒxêYï Òñ 'Ïé‡kþSÒT·	M
•
/0o;\ºã¶	f5 ¢ø`{üÿNa¶‘“ˆªOu/=jä	I
‘
/i³4¨Ì[ò–ü_	 #­&ÄWÆóa|÷#Ò7LâQÀ†—v­ràg‰ÜßEV¾Â*ÕìýR
š
½º«&ê §›gå¾Â&„þŸG*ÿ0 ¶ä	Ò!Ð×Ê2ÿ¿/õ0Ö¢ÿ]ÆöŒ¶ä	i³4Í	|Ùôo÷ûqµ!Oò`B–7;LPWšñJQŠ�ÀV
i
ž
±
`Ú˜`d†“—¨6bv‰r¯*Zþj¶“ˆOä	kO	Ÿži
±
°öYKø·	w‚Øä,ô© 	@<Œ	 ëþ
ò¦Ü
ñ
û
•>Ð)R(8×:T
œ
pŽ_ …Ü@)k
³
kO	ülH£¢5kÎŽÊO	Q©CqÙü0ÜŒ"2BVa3«ÿ];±JÅÊù�§ßeÇ)|Æ§FàZ	´lêê}—÷7LQÀ†—vr b Ò	#
ÿkJ?'¼W.ûbL> #
ü5 L¢ø	`f{ü F ˆ~ýMÿÕ.%žÍ0  [¢ B~nÊ5	
D"2B±§�š·	ÃwØLù¸	h-ƒå‘ŸªêôŸk—J
�
’
K©\ÀòŠ—1 ÿ©
CïšT´d‡A	Þ	1f×ío›´îBUv—©L��^Ã?1›ÒÓòéSÐ&/0½ YLyºã	ø$¿è/qÇ¥�)�¤Ó§ÞÞÔLòÐ Lÿ©ïÞ	ío›Bv��^Ã1
CšT´d‡A	1f×´îU—©L?›² +˜óYá
p
´0O9…•²“1ÝRÜ�‡$Ec fÿ©
C¼ïdn?cš¢T[´Nds‡©½ÄA	Þ	41f×íWo›´îþBUm·Cv—©¬"½L��^),ÃÎ×?1›u$‘¿èŸªêô/Ÿk—J
�
’
K©\ÀòŠ—qÇ¥£m
µ
£9Š¹N‡?¾I"	áüµëöËJY›.±x‰–ƒá ö
@|J4_1ûšl¤â
q‹1Pr	¢e
Añêß´2³Ý F
Ž
Î
É¦)qÑ€�Æ5!OÐíFo.Kr¤
AŽ	¢eôâ 	Ò¤AKV`-wŽˆ•<9+î¬\žKX©PXòÐ
å
g&O0˜ JD®µu’Ýi‹¤äú8+*BEcç#PY?[’™›AÎö	
@…ë"f´›"lý¨
#ÜÏÛ„}& ­£4	ºã[šFËd»ëÙ™ôÂè€oá¾\(Æ&Î	‚MPS}Ûë9µiJ®u’‹ú­Ëd˜ DÝ¤äc f¼dn?c¢[Ns©½Ä4Wþm·C¬"½),Î×uâ -	ÒwŽˆ•¤<AKV`~—÷ößy ÀØÈb	VÍNº	RaR>¸ý«®ˆŠ/$iÐÙ½d õ.38QwÕo§Y\ªóüOªÅÒ	Ñ
Ý
æ
ò
ü
5ªJV	–	ÿt‡¸D�#?¾ÑJ?-ÏØ*¼	vf¼dg?c¢¹s½
&OWm0¬³È¸H)¾ó- O ¡ ¤\£ÍÒD!SC<oËmŠ–z´ï	`àãñ$ES³c@	

$
Dz0Öõ '’È»�÷%&>ïšÙƒílÇî=·gŽ”Ê	Ü	�4d¯]Ó„·@‰‹.yš¨ëOýjÁ¾* Î #3Cw²ùjŒ¨óåâNZžLgsýi·\Ñ[âŠù ›¸	×	hÄ-xƒ‹ÙåSbk›Ò 7b _hÓé†Œ´S:™M¨¿Ãè	-3g&0>¾EY–¾ýey¶!Ó+†ºã
yù¡ø%Àè$Ó/8MãRÁ‡˜;w®'sÅXr0áÇh¦·Â|  LŸÏX^{_wÓå	j
²
–nài±³6]÷ÇÏ'Kb Ù _hmŠ–±Ópz‹´ãéï	 $B`•Âà'—¯¾ãñ$†Œ®´èESey•™ÕÝïú :S™�³3Mc¨¿Ã@	è	

$
M
•
-3D[gmzžúÿ0<–Öèõ &0> ¦¾'EY_c’–�«¾ÈÓöýDTey¶¨»!;�÷%*C’ÓÞ	&+†®ºÖãý
>y¦Åïùš"¨ .>�·?}‡Âj|  LŸÏýX^{”_wÓ<	i	å	a
j
©
²
Ê
%–�ønà*i±I³6K]÷7€ô±Ç€:£ÏÙÞ'K�®Ä¡/ Ti Oöµå ë ¨¸EWõUœÿC	^	c
l
«
´
'sãh¢g_1Y?è,_*	[	t
¼
¼ï=aO~9œ	ô	8>ÈÙ Õ‡¢-ûU OzEÜß{„w¹Ð?E|	…	ý	
+1VYeîÎ@]“i­Z«J Ël
P	�	¡¸ìñÿ/ M V î mŠ–FQz´ï	T`§àãñ$I|€šúEiöS¡³Ñ@c @	q	}	†	›	ó	


$
ƒ
DzÝ0OÇÖõJ ÏØö'A’È^”˜n»j�Ë÷%®&µà>ïš› M�éCaäÚ=	Š)Ê°	}ÅÎ
€æ[›îýZ   -<AlignableSequences trimStringency="Medium"/>  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  <?xml version="1.0"?><Features nextValidID="13"><Feature recentID="0" name="luciferase" directionality="1" translationMW="60645.64" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="2216" maxFusedRunOn="2216"><Segment range="441-2090" color="#ffcc00" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;synthetic &lt;i&gt;luc2&lt;/i&gt; version of the luciferase gene&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;firefly luciferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MEDAKNIKKGPAPFYPLEDGTAGEQLHKAMKRYALVPGTIAFTDAHIEVDITYAEYFEMSVRLAEAMKRYGLNTNHRIVVCSENSLQFFMPVLGALFIGVAVAPANDIYNERELLNSMGISQPTVVFVSKKGLQKILNVQKKLPIIQKIIIMDSKTDYQGFQSMYTFVTSHLPPGFNEYDFVPESFDRDKTIALIMNSSGSTGLPKGVALPHRTACVRFSHARDPIFGNQIIPDTAILSVVPFHHGFGMFTTLGYLICGFRVVLMYRFEEELFLRSLQDYKIQSALLVPTLFSFFAKSTLIDKYDLSNLHEIASGGAPLSKEVGEAVAKRFHLPGIRQGYGLTETTSAILITPEGDDKPGAVGKVVPFFEAKVVDLDTGKTLGVNQRGELCVRGPMIMSGYVNNPEATNALIDKDGWLHSGDIAYWDEDEHFFIVDRLKSLIKYKGYQVAPAELESILLQHPNIFDAGVAGLPDDDAGELPAAVVVLEHGKTMTEKEIVDYVASQVTTAKKLRGGVVFVDEVPKGLTGKLDARKIREILIKAKKGGKIAV"/></Q></Feature><Feature recentID="1" name="HygR" directionality="1" translationMW="38445.46" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="2968-4005" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to hygromycin&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;hygromycin B phosphotransferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MKKPELTATSVEKFLIEKFDSVSDLMQLSEGEESRAFSFDVGGRGYVLRVNSCADGFYKDRYVYRHFASAALPIPEVLDIGEFSESLTYCISRRAQGVTLQDLPETELPAVLQPVAEAMDAIAAADLSQTSGFGPFGPQGIGQYTTWRDFICAIADPHVYHWQTVMDDTVSASVAQALDELMLWAEDCPEVRHLVHADFGSNNVLTDNGRITAVIDWSEAMFGDSQYEVANIFFWRPWLACMEQQTRYFERRHPELAGSPRLRAYMLRIGLDQLYQSLVDGNFDDAAWAQGRCDAIVRSGAGTVGRTQIARRSAAVWTDGCVEVLADSGNRRPSTRPRAKEVGRV*"/></Q></Feature><Feature recentID="2" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="5983" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="5192-5983" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="5984-6052" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MSIQHFRVALIPFFAAFCLPVFA,HPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRIDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPVAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW*"/></Q></Feature><Feature recentID="3" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="4404-4992" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="SV40 promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2580-2937" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 enhancer and early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2788-2923" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="SV40 poly(A) signal" type="polyA_signal" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="2265-2386" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="hPEST" directionality="1" translationMW="4153.79" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="2216" maxFusedRunOn="2216" detectionMode="exactProteinMatch"><Segment range="2094-2213" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human codon-optimized&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;PEST degradation sequence from mouse ornithine decarboxylase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="SHGFPPEVEEQAAGTLPMSCAQESGMDRHPAACASARINV"/></Q></Feature><Feature recentID="8" name="pause site" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="167-258" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;RNA polymerase II transcriptional pause signal from the human&amp;nbsp;Î±2 globin gene&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="105-153" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;synthetic polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4029-4077" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;synthetic polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="minP" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="377-408" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;minimal TATA-box promoter with low basal activity&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="SBE" type="protein_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="285-332" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;Smad protein complexes&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;Smad-binding element (3 copies)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
  Õ<?xml version="1.0"?><Primers nextValidID="2"><HybridizationParams minContinuousMatchLen="15" allowMismatch="1" minMeltingTemperature="40"/><Primer recentID="0" name="RVprimer4" sequence="GACGATAGTCATGCCCCGCG" description="&lt;html&gt;&lt;body&gt;&lt;/body&gt;&lt;/html&gt;"><BindingSite location="4143-4162" boundStrand="1" annealedBases="GACGATAGTCATGCCCCGCG" meltingTemperature="62"><Component hybridizedRange="4143-4162" bases="GACGATAGTCATGCCCCGCG"/></BindingSite><BindingSite simplified="1" location="4143-4162" boundStrand="1" annealedBases="GACGATAGTCATGCCCCGCG" meltingTemperature="62"><Component hybridizedRange="4143-4162" bases="GACGATAGTCATGCCCCGCG"/></BindingSite></Primer><Primer recentID="1" name="RVprimer3" sequence="CTAGCAAAATAGGCTGTCCC" description="&lt;html&gt;&lt;body&gt;&lt;/body&gt;&lt;/html&gt;"><BindingSite location="206-225" boundStrand="0" annealedBases="CTAGCAAAATAGGCTGTCCC" meltingTemperature="54"><Component hybridizedRange="206-225" bases="CTAGCAAAATAGGCTGTCCC"/></BindingSite><BindingSite simplified="1" location="206-225" boundStrand="0" annealedBases="CTAGCAAAATAGGCTGTCCC" meltingTemperature="54"><Component hybridizedRange="206-225" bases="CTAGCAAAATAGGCTGTCCC"/></BindingSite></Primer></Primers>
  Æ<Notes>
<UUID>294ed924-f5d7-4b2c-99a1-2a98b126e79a</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<CustomMapLabel>pGL4.48[luc2P SBE Hygro]</CustomMapLabel>
<UseCustomMapLabel>1</UseCustomMapLabel>
<Description>&lt;html>&lt;body>Vector with a minimal promoter and a Smad-binding element for studying cell signaling using destabilized luciferase.&lt;/body>&lt;/html></Description>
<Created UTC="5:0:0">2012.7.2</Created>
<LastModified UTC="6:40:37">2025.7.8</LastModified>
<AccessionNumber>JQ858517</AccessionNumber>
<CreatedBy>Promega</CreatedBy>
<Organism>Mammalian Cells</Organism>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>Unspecified</TransformedInto>
</Notes>
  Y      K         
?????                                                                                                       ÿ d      HO  d                E              ÿÿÿÿYô? P                                                                                                                                                              3<?xml version="1.0"?><EnzymeVisibilities vals=""/>
  ¾<?xml version="1.0"?><CustomEnzymeSets><CustomEnzymeSet type="1" name="Unique Cutters + BglI, SfiI" enzymeNames="AanI AarI Acc65I AlwNI ApaLI AvrII BamHI BbvCI BciVI BfuAI BglI BglII BlpI BpmI BsaAI BsmBI BspMI BsrGI BssHII BstBI BstEII BstXI BstZ17I Bsu36I DraIII Eco53kI EcoRI EcoRV FseI HindIII KasI KpnI MfeI MreI NarI NotI PaeR7I PciI PluTI PmeI PsiI PspXI PstI PvuI SacI SacII SalI SfiI SfoI SgrAI SpeI StuI XhoI XmnI"/></CustomEnzymeSets>
